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As a result, red blood cells grow too big and dont work well

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Downregulation of the p53 signaling pathway promotes cellular proliferation and modulates inflammatory responses 71 , while HDAC7 depletion facilitates cell migration, angiogenesis, and extracellular matrix remodeling, collectively contributing to coordinated tissue repair 72

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A natural decline occurs over time in the levels of collagen, with production of new collagen decreasing and existing collagen reducing structural and functional integrity