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Metabolism-dependent ferroptosis promotes mitochondrial dysfunction and inflammation in Cd4(+) T lymphocytes in HIV-infected immune non-responders

Lin H-R, Wu Y-H, Yen W-C et al (2016) Diminished COX-2/PGE2-Mediated Antiviral Response Due to Impaired NOX/MAPK Signaling in G6PD-Knockdown Lung Epithelial Cells

Over the last decade, several accessory chaperones have been identified which are specifically activated in response to oxidative stress (recently reviewed in [284])

Some of them (coumestrol, genistein, apigenin, naringenin, kaempferol) have a higher binding affinity to ER than ER and stimulate transcriptional activity [132,133]

Depending on the metabolic situation, these effectors trigger transient changes in zinc concentrations

Group 1 (Control) was treated with normal saline intraperitoneally (i.p.), while Group 2 (B12) received an i.p