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Research on skeletal muscle biopsies from DMD patients has revealed decreased NAD + levels, increased PARP activity 253 and dysfunction of mitochondrial metabolism 254,266

Modular pathway engineering of diterpenoid synthases and the mevalonic acid pathway for miltiradiene production

We have discussed that ATP production by mitochondria is directly or indirectly affected by reduced turnover and altered post-translational modifications of ETC proteins, impaired assembly or instability of mitochondrial complexes, abnormal protein aggregation, and dysregulated lipid metabolism

10.1038/s41598-021-81741-3 136 KimJ
