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During arousal and orgasm, compounds are released that can affect male biology: - Copulins:fatty acids in vaginal secretions, often described aspheromone-like compounds, that may act as chemosignals influencing male hormonal responses and sexual motivation - Lactobacilli:a healthy vaginal microbiome supports microbial balance and may also contribute to overall urogenital health 3

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Other adverse effects, including depression, sleep disturbances, and anxiety, have also been noted.While these side effects are usually transient, they can be bothersome enough to prompt some patients to discontinue treatment prematurely