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Conversely, the mitochondrial damage and calcium homeostasis imbalance triggered by NLRP3 activation further exacerbate mtROS production, creating a positive feedback amplification loop

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Gastrocutaneous (Skorjanec et al., 2009) and/or duodenocutaneous (Skorjanec et al., 2015) fistulas, as persistent lesions, are another instructive prototype of the two-ways model

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