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This includes patients receiving intramuscular injections (typically 1,000 micrograms) for pernicious anaemia or documented B12 deficiency, as well as individuals taking high-dose oral supplements exceeding the Reference Nutrient Intake (1

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Diagnosis (vitamin B12 deficiency or pernicious anaemia) was treated as a binary response in analysis, as everybody in the pernicious anaemia group was also classed as having vitamin B12 deficiency, as pernicious anaemia is the most common cause of vitamin B12 deficiency

There is evidence that treatment with B12 injections can help alleviate the condition, according to the research