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The chosen method depends on the patients condition and the healthcare providers recommendation

The approval was backed by the Phase II open-label AGAVE-201 trial, where treatment with a 0.3-mg/kg dose of Niktimvo elicited an overall response rate of 75%, with a median time to response of 1.5 months

MarakiMIYannakouliaMStamelouMStefanisLXiromerisiouGKosmidisMHet al

showed that metastasis-associated fibroblasts (MAF) expressed high levels of CD38 and activated macrophages into a pro-tumoral M2-like macrophage [52]