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If a person has a liver disorder, for example liver disease, then the liver is unable to store vitamin B12 and this can lead to a B12 deficiency
10.3389/fncir.2013.00144 232
Reduced NAD+ impairs mitochondrial respiration, sirtuins (SIRT1, SIRT3), and AMPK signaling, all of which are required for efficient fat oxidation
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Since copper accumulates in senile plaques of AD patients, some authors proposed dietary restriction of copper or intake of copper chelators as a preventive therapy for the elderly
