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This proves that while smaller nanoparticles are more likely to cross the BBB in most cases, it is not absolute

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In summary, rats that had acute abdominal compartments, when undergoing decompression and reperfusion after BPC 157 therapy, exhibited no portal and caval hypertension, ameliorated aortal hypotension, markedly attenuated superior sagittal sinus hypertension, and no disturbed QTc interval

From blood-brain barrier to blood-brain interface: new opportunities for CNS drug delivery

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Gosk S, Vermehren C, Storm G, Moos T