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M., Tang, Y

UHRF1 suppression also prevents cell proliferation by inducing cell cycle arrest and apoptosis through DNA demethylation, which suggests that UHRF1 could be a potential biomarker and therapeutic target for cancer diagnosis and treatment (Seo et al., 2017)

3. Boosted Immune System

Gain-of-function mutation in NLRP3 causes a spectrum of autoinflammatory diseases termed cryopyrin-associated periodic syndromes (CAPS) (Yu and Leslie, 2011)

doi: 10.1161/ATVBAHA.121.316021 121 HeSTianRZhangXYaoQChenQLiuBet al

Both cell suspensions were pelleted and resuspended in PBS (100 L/mouse) and 4 10 6 total cells/mouse (2 10 6 CFSE lo and 2 10 6 CFSE hi ) were injected IV into mice 12 days after second vaccination