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This metabolic perturbation significantly downregulates the expression of intestinal tight junction proteins, particularly ZO-1 (Mishra et al., 2023), thereby initiating a multistep pathogenic cascade: (i) compromised intestinal barrier integrity promotes bacterial translocation and systemic dissemination of deleterious metabolites
10.5603/arm.27573 374 Ruiz-NezB.PruimboomL.Dijck-BrouwerD

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Eur J Biochem 269, 24142420
