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It has been demonstrated that patients who continue treatment develop more lesions, whereas 90% of those who discontinue the treatment do not develop further lesions or recurrence of previous lesions.11 When a patient on treatment with sorafenib is diagnosed with SCC, a short interruption of treatment or a dose reduction may be contemplated until the tumors can be excised

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TMLHE mutations are surprisingly common Two recent studies have found that the prevalence of TMLHE mutations in human populations may range from about 1 in 350 to about 1 in 900

[DOI] [PubMed] [Google Scholar] 565.Zeng W, Pirzgalska RM, Pereira MMA, Kubasova N, Barateiro A, Seixas E, Lu Y-H, Kozlova A, Voss H, Martins GG, Friedman JM, Domingos AI

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