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doi: 10.2967/jnumed.107.049478

A catalytic cycle of GPx (Figure 2) starts with the oxidation of the selenol (ESeH) moiety of Sec residue by peroxide to generate the selenenic acid (ESeOH) [37, 38], which reacts with cellular thiol (glutathione, GSH) to generate a selenenyl sulfide intermediate (ESeSG)

Indeed, among other effects, elevated homocysteine levels could alter arterial reactivity to adrenergic stimulation, modifying vascular sensitivity to norepinephrine, thus prompting vasorelaxation (Cipolla et al

However, it's important to note that the hydrochloride (HCl) molecule adds extra weight

doi: 10.1124/pr.54.2.271 29

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