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There is no such thing as over dosage in whitening supplements

Hiona, A

Toteberg-Harms M, Meier-Gibbons F

Most commonly drug-induced nephrotoxicity is manifested by tubular necrosis, interstitial nephritis, crystal nephropathy, Angiopathy, alterations in intraglomerular hemodynamics, rhabdomylosis and fibrosis which may ultimately leads to renal failure.13 The drug-induced nephrotoxicity has been accounted for 66% renal failure cases of elderly population.4 Despite the advancements in medical research, drug-induced nephrotoxicity is continuously evolving into high morbidity and mortality in 4070% of patient with acute renal injury.5 Moreover, it also limits the effectiveness of drugs and complicates the medical conditions in the treatment of serious malignancies, renal transplantation and several metabolic disorders.610 Melatonin, a pineal gland product, was first isolated in 1958 correlating its role with melanocytes.11 Melatonin (N-acetyl-5-methoxy tryptamine) was found to be present in all organisms and initially known for its physiological role in control of circadian rhythm