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doi: 10.1095/biolreprod64.2.674 102 ImaiHHakkakuNIwamotoRSuzukiJSuzukiTTajimaYet al

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Besides biological systems similarly altered in vitamin D deficiency and RLS, the role of vitamin D in the modulation of neurotransmitters reportedly altered in RLS, might indicate a rationale to consider D3 supplementation, at least as an add-on therapy, in resistant RLS with known vitamin D deficiency, once all other traditional RLS therapeutic options have been exploited

Functionally different agonists induce distinct conformations in the G protein coupling domain of the 2 adrenergic receptor