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The intestinal microbiota exerted an influence on the central nervous system through its interactions with intestinal neurons, releasing neurotransmitters and inflammatory factors, which in turn, can exacerbate symptoms of insomnia

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The most widely studied is the thermosensitive cell sheet, in which the substrate changes from hydrophobic to hydrophilic when the temperature falls below a critical temperature, which causes the cells to detach from the substrate

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478 Notably, reduced hepatic LTB4 levels correlate with diminished recruitment of neutrophils and macrophages in response to the 5-LOX inhibitor zileuton