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58 The column was perfused with an isocratic mobile phase containing glacial acetic acid (6.01 g/L) and 0.1 M n-dioctylamine in HPLC grade methanol/water (96.5/3.5%)

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Under zinc-deficient conditions, mutant SOD1 can generate highly active hydroxyl radicals and peroxynitrite via abnormal copper chemistry, further exacerbating neuronal oxidative damage and protein nitration (120)

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doi: 10.3389/fncel.2015.00066 Received 08 January 2015 Accepted 12 February 2015 Published 11 March 2015 Volume 9 - 2015 Edited by Andy Groves, Baylor College of Medicine, USA Reviewed by Olivia Bermingham-McDonogh, University of Washington, USA

Safety profile of the combination Safety is the most critical consideration with any combination protocol, and the AOD 9604 plus tirzepatide stack has a favorable profile compared to other multi-compound approaches