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130 TP53 also promotes ferroptosis through regulating lipid peroxidation via the transcriptional induction of SAT1 64 or GSL2 40 in human osteosarcoma cells or MEFs, respectively

This process is orchestrated by PRLMs, which are bioactive molecules derived from polyunsaturated fatty acids (PUFAs)

It blocks tyrosinase, the enzyme required to produce melanin

Bioorg Med Chem 26(1):232244 Mellado M, Salas CO, Uriarte E, Via D, Jara-Gutirrez C, Matos MJ et al (2019) Design, synthesis and docking calculations of prenylated chalcones as selective monoamine oxidase B inhibitors with antioxidant activity

proposed that blockade of the phosphatidylinositol 3-kinase (PI3K)/AKT/mTOR signaling cascade by rapamycin treatment could ameliorate alcohol-induced osteoporosis by rescuing impaired osteo/adipogenic lineage differentiation in BMSCs (125)

doi: 10.1016/j.actbio.2021.04.009
