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Mast cells, a potent contributor to the release of inflammatory mediators, including histamine, are identified in increased quantity in rosacea patients, and receptors for histamine and serotonin, leading to vasodilatory effects, are upregulated in all forms of rosacea

As the interaction time is determined by the pulse width, bubbles containing different nuclei densities can be formed under the same laser energy but different pulse widths

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