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doi: 10.1073/pnas.0705891104

A c c e p t e d : June 24, 2016

CHOL-HxT, hydroxytyrosol RP cholesterol enriched high-saturated/high-cholesterol diet

Oral DMTs: An alternative to injectable therapies In 2010, fingolimod (Gilenya , Novartis, Switzerland) was the first oral MS DMT approved by the FDA, with teriflunomide (Aubagio , Genzyme, France) following in 2012 and cladribine (Mavenclad , Merck, Germany) in 2017 approved by the EMA

As a matter of fact, it has been demonstrated that the presence of the S-enantiomer in the racemic mixture prevents the polymerization of R-ALA to some extent, increasing its bioavailability [6]

5,6 Added zinc and chromium support normal macronutrient metabolism, plus chromium contributes to the maintenance of normal blood glucose levels and zinc contributes to normal carbohydrate and fatty acid metabolism