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[DOI] [PubMed] [Google Scholar] Sirshar M

Emerging evidence highlights bidirectional communication between the gut microbiota and the CNS via neuroendocrine and neuroimmune pathways, collectively termed the gut-brain axis [228]

Aberrant inflammation is among these [16], associated with other factors, including oxidative stress induced by Reactive Oxygen Species (ROS), glial and astrocyte injury, compromised monoamine secretion, dysregulation of glutamatergic pathways, neuro excitotoxicity, damage to cerebral blood vessels [15, 17], dysfunction in glymphatic processes [18], and disruption of hippocampal function and dorsolateral prefrontal cortex (DLPFC) [19]

10.1016/j.theriogenology.2003.11.013 28

THYROID DERMOPATHY AND ACROPACHY Thyroid dermopathy (also called pretibial myxedema or localized myxedema) is an uncommon extrathyroidal manifestations of Graves disease (less frequently of chronic autoimmune thyroiditis) (13, 173)

Research in animal models demonstrates improved insulin sensitivity, enhanced fat oxidation, and protection against diet-induced obesity