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Compared with APP-treated saline, the elevation of reactive oxygen species (ROS) levels in serum was significantly smaller, implying that an antioxidant system existed in serum

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For individuals with impaired absorption, genetic variations such as MTHFR mutation, or increased metabolic demand, methyl-B12 injections provide a direct and highly effective method to restore and maintain optimal levels

Taken together, this is the first study to describe the hepatic metabolome after ischemic AKI in a murine model and demonstrates that there is significant liver-kidney crosstalk after AKI.

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