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doi: 10.1124/dmd.107.019661
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BH 4 is synthesized de novo from GTP by guanosine triphosphate cyclohydrolase I (GTPCH), 6-pyruvoyltetrahydropterin synthase (PTPS) and sepiapterin reductase (SR) and GTPCH is the rate-limiting enzyme in BH 4 biosynthesis [91]
These biomarkers are also used to track the efficacy of antioxidant therapies, with decreasing levels of MDA and 4-HNE indicating effective intervention [35]
