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Ravali Yalamanchili on 07th March 2025

Statistics and reproducibility Statistical methods to predetermine sample size were not used

Though there is not conclusive evidence comparing the extent of functional benefits provided by the 2 therapies, based on the data presented within the MAIC analysis of the drugs clinical trials, one can hypothesize that pegcetacoplan may have a greater effect than avacincaptad pegol on preserving visual function, and patients may be able to protect their driving and reading abilities for a longer period of time

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These findings suggest that LT effectively alleviates the DHEA-induced imbalance in sex hormone metabolism in mice by lowering hyperandrogenism (T and LH) and prolactin levels, restoring the gonadotropin ratio (LH/FSH), and increasing progesterone secretion, indicating its potential for regulating hormone disorders
