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Additionally, DNA damage by oxidative stress frequently activates the SOS response pathway, which induces the UvrABC excision nuclease as well as the Rec recombinational machinery (Imlay and Linn, 1987)

[DOI] [PubMed] [Google Scholar] 69.Fruh V., Preston E.V., Quinn M.R., Hacker M.R., Wylie B.J., OBrien K., Hauser R., James-Todd T., Mahalingaiah S

Encouragingly, emerging targeted metabolic strategies have demonstrated a 55% reduction in severe adverse events, establishing a crucial framework for developing metabolic interventions that optimally balance therapeutic efficacy with safety [85]

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The reactions with some compounds, such as benzyl and phenethyl isothiocyanates and alkyl dihalides, can be reversible, increasing their toxicity [210]