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Wang et al., 2018b), serine metabolism is dysregulated in many tumours (Mattaini et al., 2016), asparaginase is an integral component of multiagent chemotherapy regimens for the treatment of acute lymphoblastic leukaemia (Salzer et al., 2018), histone hypermethylation can be induced in V600EBRAF melanoma cells by withdrawing glutamine (Pope et al., 2019)

The development of new treatments for HF remains a priority because of the high risk in these patients despite new therapies being developed in recent years 9 The ANS is a potential therapeutic target, as imbalances in ANS signaling are associated with worse outcomes and current drug therapies are limited to targeting the sympathetic branch of the autonomic dysfunction seen in HF 10

Ideally, the diet would provide the right amount of plant fiber to keep the good bacteria in the gut well-fed