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For instance, GSH can be depleted, through inhibition of its synthesis using an inhibitor of GCL (buthionine sulfoximine, BSO) (57) under conditions that maintain the intracellular cysteine pool intact,

[DOI] [PubMed] [Google Scholar] 214.Burkhardt S., Tan D.X., Manchester L.C., Hardeland R., Reiter R.J

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As a prototype antioxidant, it has been involved in cell protection from the noxious effect of excess oxidant stress, both directly and as a cofactor of glutathione peroxidases

2.4 Mitochondrial dysfunction in PD Mitochondrial dysfunction is intricately linked to PD etiology and ferroptosis