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doi: 10.2337/db15-0122

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Despite this long clinical history, widespread public awareness only emerged recently due to expanded weight-loss applications and celebrity discussions, creating the illusion that these are brand-new treatments rather than established medications with proven track records

The relationship between all the loci of the chromosomes of the two datasets and their corresponding P -values is shown in the Manhattan plot, the red dotted line stands for P = 1e-5 (Fig