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Tirzepatide is an FDA-approved medication for type 2 diabetes and chronic weight management, available exclusively as pre-filled injection pens under the brand names Mounjaro and Zepbound

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Figure 3: The average levels of AngIV in the brain in the four different experimental groups included in the first part of the study

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Abenavoli L, Capasso R, Milic N, Capasso F

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The potential involvement of a dopaminergic mechanism in this process was inferred from the blocking action of pimozide, a dopamine antagonist, on the DSIP-induced GH increase

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Each tissue shows unique patterns of NAD+ reduction, which suggests different vulnerabilities to aging

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In contrast, cortical microglia largely returned to baseline following cuprizone withdrawal, with full recovery of morphological heterogeneity (p = 0.0025), cell area (p = 0.0096), and density (p = 0.0002) - consistent with a reduced burden of demyelination and debris clearance in this area

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