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C.ShimizuC.FudaH.StrottC

doi: 10.1172/JCI18181

Although no GLO1 inhibitor has yet been developed that has potential for use in therapy, mainly due to adverse side effects [261], exogenous application of MGO to further increase aldehyde stress has shown promising effects in a mouse model [262]

Messenger RNA-based vaccines with dual activity induce balanced TLR-7 dependent adaptive immune responses and provide antitumor activity

Pathogenic and non-pathogenic variants are proposed to exist

Through the inhibition of adipocyte fat breakdown and subsequent reduction in free fatty acid release, metformin contributes to improved lipid metabolism