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PLoS One 7:e51743

Mutations were identified by alignment of sequenced alleles to the wild-type allele
In that case, they may start at higher doses and de-escalate to lower doses

Spermatozoa concentration and motility were counted in triplicate before and immediately after the addition of NEP inhibitors (opiorphin, phosphoramidon, and thiorphan)

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It is relevant to note that, in patients with upper gastrointestinal symptoms, there are about 25% of patients with delayed gastric emptying, about 25% with impaired gastric accommodation, and about 25% with the combination of both gastric motor dysfunctions (Park et al., 2017
