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Calabrese and Kozumbo, 2021)

Fujii YX, Fujigaya H, Moriwaki Y, Misawa H, Kasahara T, Grando SA, Kawashima K

doi: 10.1016/s0969-2126(00)00104-0

They are inconsistent with the hypothesis that LYSET has no impact on GNPT cleavage, as suggested by the trafficking model, but they do support the notion that LYSET serves as an anchor to maintain GNPT at the Golgi, regardless of cleavage

In addition, there is scientific evidence that confirms a potential disruption of the integrity of the lipids of the corneous layer of the skin, a disadvantage generated by substances that further enhance the permeation of the active substance through the skin [215]