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[DOI] [PubMed] [Google Scholar] Feng Y

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Although high-throughput screening can rapidly screen a variety of compounds, the specificity of the screened compounds for NOX proteins and their selectivity for different NOX subtypes cannot be guaranteed

For instance, a study demonstrated that blocking MCU significantly reduced ROS production and mitochondrial swelling in iron-overloaded thalassemic mice, suggesting that MCU could be a therapeutic target for preventing mitochondrial dysfunction in IOC ( Genetics factors Polymorphisms and mutations in specific genes can participate in cardiac iron overload

doi: 10.1038/s41467-020-18262-6 102 ChunELavoieSFonseca-PereiraDBaeSMichaudMHoveydaHRet al

The Relationship between Oxidative Stress and Autoimmunity in Hashimotos Thyroiditis