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For individuals with MTHFR mutations, L-methylfolate (5-MTHF) is generally considered the best form of folate supplementation, as it bypasses the metabolic issues associated with these mutations

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That is the reason it is considered relatively safe even at high doses

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(iv) Assessment of a patients toxic metal burden during life could be made by elemental mapping of non-CNS tissue such as striated muscle that is likely to retain toxicants for long periods of time and that can be safely biopsied (Figure 10)

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