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Research suggests it acts through modulation of several interconnected signaling pathways simultaneously a broad mechanism of action that helps explain its observed multisystemic effects in laboratory models, and that also makes it challenging to evaluate through conventional single-target drug development frameworks

Nevertheless, the study fails to clarify differences in serum PCS levels among PBC patients at different disease stages, uses non-human primary Kupffer cells in vitro , and does not evaluate the safety threshold for clinical PCS supplementation, which limits its therapeutic translation

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It allows the treatment to be tailored according to the patients strength, metabolic capacity, and disease burden, rather than applying a uniform approach

In fact, some studies suggested modest improvements in insulin sensitivity, likely secondary to fat loss and particularly visceral fat reduction