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Carbamazepine, phenytoin, and vigabatrin should be avoided, for they frequently provoke seizure exacerbation (17,24,25)

One could propose that the drastic decrease in the leucocyte number in the Cisplatin group on the seventh day of the experiment (Table 3) was associated with its specific cytostatic action, and the subsequent growth of the leucocyte number beyond the normal values resulted from the inflam- matory reaction under cytostatic action

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Briefly, the KolmogorovSmirnov D-statistic is proportional to the maximum vertical distance between two eCDF plots, and ranges from 0 (distributions entirely overlapping) to 1 (distributions completely separated), functioning as a relative effect size metric for the comparison between two empirical distributions 77,78

Dietary modifications are essential, including encouraging patients to consume small, frequent meals to reduce gastric distension and improve emptying, adopting a low-fiber, low-fat diet to minimize delays in gastric emptying, and incorporating liquid nutrients that are easier to digest

However, injectable applications require consideration of total copper load, particularly in patients with conditions affecting copper metabolism such as Wilsons disease or Menkes disease