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Clinical and organ assessments and contraindications We suggest that all paediatric patients who are being considered for GH therapy undergo a fundoscopic examination to rule out pre-existing papilledema, which could be suggestive of intracranial hypertension that might progress during GH therapy 44

Its epigenetic modulation capabilities also suggest it can influence DNA methylation patterns and histone modifications, potentially providing long-term regulatory mechanisms for inflammatory processes [44]

Thyroid hormones, oxidative stress, and inflammation

Inhibitors of the quinone-binding site allow rapid superoxide production from mitochondrial NADH:ubiquinone oxidoreductase (complex I)

Peters, S

doi: 10.1093/jnen/nlaa002 62 de CarvalhoM