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Inflammation, hypercoagulability, microvascular thrombosis, endothelial dysfunction, and mitochondrial dysfunction can induce acute kidney injury (AKI), which could further develop into chronic kidney disease (CKD) under chronic inflammation and cytokine storm (Rai, 2023)

[DOI] [PMC free article] [PubMed] [Google Scholar] McLean M., Chen R., Yu D., Mah K., Teat J., Wang H

Polynucleotides in aesthetic medicine: A review of current practices and perceived effectiveness

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However, different reports investigated that cordycepin can suppress the production of proinflammatory cytokines (such as IL-1, IL-6, TNF- and NO) in LPS stimulated macrophages, leading to downregulation of type 2 diabetes-regulating genes (11-hydroxysteroid dehydrogenase type 1 and peroxisome proliferated activated receptor-) [64]

ROS are involved in the structural modification of the vascular wall thickness and lumen diameter [75]