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[DOI] [PubMed] [Google Scholar] 152.Devereux G

The catalytic subunit of glutamate cysteine ligase (encoded by the gene Gclc ) catalyzes a rate-limiting step in glutathione synthesis from the substrates glutamate and cysteine [216]

Glutathione (L--l-glutamyl-L-cysteinyl-glycine) is the most abundant eukaryotic and prokaryotic low molecular weight thiol, with cellular concentrations in the millimolar range, and it is a main regulator of redox status and redox signal transduction within cells [9,10,11]
However, cuproptosis presents a potential opportunity for overcoming this resistance and promoting cell death in cancer cells

doi: 10.30574/WJARR.2021.10.3.0280

British journal of cancer 131(6):1005-1013, 2024
