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PtdIns3K, together with other Atg-related proteins, recruits Atg12-Atg5-Atg16L1 and the light-chain 3 (LC3) ubiquitin-like conjugation systems necessary for the expansion, elongation, and maturation of autophagosomes (362)

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The ineffective erythropoiesis also promotes iron absorption from the gastrointestinal tract, compounding iron overload, even in the absence of transfusions

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