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doi: 10.1016/j.pnpbp.2006.04.012 121 PatrignaniPTacconelliS

This principle supports the micro-dosing approach for maintenance and chronic condition management

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Liu LC, Voors AA, van Veldhuisen DJ, van der Veer E, Belonje AM, Szymanski MK, Sillj HH, van Gilst WH, Jaarsma T, de Boer RA

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Data from the National Survey on Drug Use and Health revealed that 80% of new heroin users previously abused prescription opioids, indicating a link between prescription analgesic misuse and heroin use.32 Tolerance significantly reduces the analgesic efficacy of opioids in patients with substance use disorders