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Intriguingly, spread of pSYN from the periphery to the brain is observed, accompanied by motor deficits (218, 219)

Guillot X, Tordi N, Laheurte C et al (2019) Local ice cryotherapy decreases synovial interleukin 6, interleukin 1, vascular endothelial growth factor, prostaglandin-E2, and nuclear factor kappa B p65 in human knee arthritis: a controlled study

Both nonoperative management techniques and surgical intervention are used in the treatment of CTS

Conceptually this stable dynamic state of synaptic plasticity is comparable to the blood coagulation cascade, which is kept in a delicate balance between bleeding and site-specific thrombosis

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