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Environmental insults such as airborne pollutants, cigarette smoke, and occupational exposures (e.g., asbestos, silica) are well-documented oxidative stress in the lung

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These findings demonstrate that compounds activity partially depends on TrkB kinase activation and could suggest also non-TrkB mediated effects of GSB-106

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50 Hemoglobinuria is present in only 25% of patients at diagnosis, but it will occur in most patients during the course of the illness

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