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When benchmarked against other IgG1 Fc variants engineered for altered FcRn binding and plasma half-life in vitro and in vivo, REW performed better or on par with these (SI Text 5, Fig

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Of note, the mRNA expression pattern in PV neurons of schizophrenia patients indicate an immature state [92], including altered expression of genes regulating cell cycle and apoptosis [93]

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GDNF mRNA +1.21.4 (indirect neurotrophin upregulation)