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The absence of functional XBP1 pathway produces Parkinsons Disease (107) and 4-PBA is known to attenuate the severity of several brain diseases, such as Parkinsons (108), Alzheimers (109), and cerebral ischemia (105)

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10.1016/j.taap.2021.115596 38 LiN.WangW.ZhouH.WuQ.DuanM.LiuC.et al (2020)

Current therapeutic strategies include topical aluminum salts, tap-water iontophoresis, application of anticholinergic agents such as Botulinum toxin, local surgical approaches, and sympathectomies