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We identify a compound that degrades MYC, A80.2HCl, which induces MYC degradation at nanomolar concentrations, restores pRB1 protein levels and re-establish sensitivity of MYC high-expressing cancer cells to CDK4/6i

2d) and coefficient scores (Fig

Consequently, ectopic overexpression of NPLOC4 reverses CuET-mediated cytotoxicity (Skrott et al., 2017), although the role of VCP in this process remains unknown

Fuchs R, Taylor D, Jenkins DW, Brache V, Luo D, Dor LJ, et al

Emerging interventions aim to restore immune function through metabolic and inflammatory regulation

2)) and contains 11 conjugated and 2 unconjugated double bonds (Fish et al., 2002[42])