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Patients with pernicious anaemia, malabsorption disorders (such as Crohn's disease or coeliac disease), or following gastric surgery require regular B12 supplementation to prevent serious complications including megaloblastic anaemia and neurological damage

Animal studies have not reported major toxicity, but the lack of comprehensive human data means risks are unknown467

The skin is a target organ, not an obstacle

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Every step of the process occurs under rigorous quality control protocols in certified U.S

Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency: randomised placebo controlled trial