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doi: 10.3389/fnins.2017.00043

Potential Side Effects Reported side effects include nausea, dizziness, hot flashes, blood pressure fluctuations, allergic reactions (rash, swelling), and, with prolonged use, possible liver and kidney issues

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However, with the advancement of scientific knowledge the classification has also been shifted based on their selectivity for inhibiting cyclooxygenase/prostaglandin-endoperoxide synthase (PGHS) enzymes which are the major targets of these drugs

No, it usually doesnt happen