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There is a theoretical concern, supported by some biological evidence, that elevated IGF-1 activity in a patient with occult or a history of certain hormone-sensitive cancers could be problematic

doi: 10.1111/j.1524-4725.2012.02378.x

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In some cases, this may affect how well certain nutrients, including vitamin B12, are absorbed

These antioxidant activities indicate a potential role in hypertension treatment that should be explored further for vasorelaxant activity

After 28 days, its preservative qualities are no longer certain, and the risk of microscopic, invisible contamination increases significantly