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Selective autophagy receptors such as NDP52, TAX1BP1 and p62 are also capable of directly recruiting the ULK1/2 complex through binding to FIP200 (subunit of the ULK1 complex) to initiate de novo autophagosome biogenesis at the site of the cargo (40, 42, 43)

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the differences in concentrations of major cations and anions among the compartments